Auristatin Tyramine Phosphate Prodrugs and Aminoquinoline Derivatives

Description

The remarkable anticancer properties of dolastatin 10, isolated from the sea hare (sea slug) Dolabella auricularia, have led to interest in closely related derivatives (auristatins) suitable for clinical trials. Most recently, such auristatins have been linked to antibodies for delivery. In many indications, however, it would be desirable to deliver such drugs without resort to conjugation.

Researchers at Arizona State University have developed prodrug forms of a novel auristatin tyramine derivative as phosphate salts, as well as auristatin quinoline modifications. These compounds exhibit superior inhibition of cancer cell growth. In addition, auristatin TP sodium salt is water soluble, and is thus expected to have greater bioavailability.

Existing auristatin drugs (e.g., SGN-35) are showing promise in clinical trials. The above novel compounds may have important advantages over such existing auristatin drugs and may prove to be important drugs for treating cancer.

Potential Applications

  • Inhibiting cancer cell growth
  • Treating many types of cancer

Benefits and Advantages

  • Novel compounds displayed very strong cancer cell growth inhibition against a panel of murine and human cancer cell lines
  • Auristatin TP sodium salt:
    • Water soluble
    • No need for conjugation to a macromolecule, such as an antibody, for delivery
    • Likely greater bioavailability than other forms of the drug
  • Auristatins 2-AQ and 6-AQ
    • Aminoquinoline modifications of dolastatin 10
    • Various biological activities have been reported for simple derivatives of aminoquinolines, and these moieties are expected to confer distinct activity
    • Suitable for attachment to an antibody

For more information about the inventor(s) and their research, please see
Dr. Pettit's departmental webpage

Case ID:
M11-099LC
Published:
06-09-2017
Last Updated:
05-16-2018

Patent Information

App Type:
Nationalized PCT
Serial No.:
14/007,743
Patent No.:
9,044,518
File Date:
03-29-2012
Issue Date:
06-02-2015
Expire Date:
03-29-2032
App Type:
Nationalized PCT
Serial No.:
2014-502781
Patent No.:
6161592
File Date:
03-29-2012
Issue Date:
06-23-2017
Expire Date:
03-29-2032
App Type:
Nationalized PCT
Serial No.:
2012236511
Patent No.:
2012236511
File Date:
03-29-2012
Issue Date:
08-11-2016
Expire Date:
03-29-2032
App Type:
Nationalized PCT
Serial No.:
2,831,307
Patent No.:
File Date:
03-29-2012
Issue Date:
10-15-2018
Expire Date:
10-15-2018
App Type:
Nationalized PCT
Serial No.:
12765637.9
Patent No.:
File Date:
03-29-2012
Issue Date:
10-15-2018
Expire Date:
10-15-2018

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