Devices and Methods for Making Molecular Arrays

Description

Molecular arrays allow scientists to perform large-scale, quantitative, biological analyses such as biomarker discovery, immunomonitoring, epitope mapping and so on. Making molecular arrays can be difficult, though, as they are sensitive to distinct parameters including the nature of biochemical molecules present in the array. Some processes apply solutions directly to the surface which can result in puddling and a highly heterogeneous array. While there are many methods and processes for forming arrays, they all fail to yield large quantities of molecular arrays with consistently high quality.

Researchers at the Biodesign institute of Arizona State University, have developed a novel device and method for consistently making superior molecular arrays. The device is a specialized instrument to facilitate homogeneous coupling reactions on an array. The method pertains to a way of using the device and performing a chemical reaction on the surface of an array. The device and method are able to maintain an even distribution of materials at a constant concentration to make consistently high quality arrays. 

This device and method enable improved thermal control for the consistent production of high quality molecular arrays in large quantities.

Potential Applications

• Molecular array manufacturing

o DNA arrays

o Peptide arrays

o PNA arrays

o Peptoid arrays

Benefits and Advantages

• Provides a homogeneous coupling of molecular monomers to at least 95% of the surface

• Consistent production with high quality

• Temperature control/improved level of heat distribution - provides a level of thermal uniformity across a surface that varies by no more than 5oC

• Can effectively distribute the amount of fluid comprising the monomers

• Allows for the removal of a used solution or for the replacement of a solution that is no longer needed

• Enables effective diffusion of fresh solution to the surface – speeds up the reaction and removes unwanted reactive species

For more information about the inventor(s) and their research, please see
Dr. Woodbury’s departmental webpage

Case ID:
M16-145L
Published:
12-22-2017
Last Updated:
12-05-2018

Patent Information

For More Information, Contact