FIRST software (Floppy Inclusions and Rigid Substructure Topography) for analyzing conformations of proteins and other biomolecules

Description

The FIRST software (Floppy Inclusions and Rigid Substructure Topography) was developed by researchers at Arizona State University for analyzing conformations of proteins and other biomolecules.

This software uses patented algorithms for identifying rigid and flexible regions within proteins and other biomolecules of thousands of residues in a few seconds.

The FRODA module (Framework Rigidity-Optimized Dynamics Algorithm) within the FIRST software uses geometric simulation algorithms to quickly explore the “clash free” conformational space in proteins or other biomolecules. FRODA is capable of generating thousand of distinct conformations within minutes on a single-processor computer.

Potential Applications

  • Pharmaceutical research (e.g. searching for possible ligands to inactivate HIV protease)
  • Understanding cellular metabolism
  • Cancer and autoimmune disease research

Benefits and Advantages

  • Novel algorithms are faster than competing software products
  • Shows flexibility and motion in biomolecules
  • It is easy to simulate the motion in large structures
  • Conformational changes in ADK proteins are produced in five minutes or less

The on-line freeware version is available at: http:/flexweb.asu.edu.

Case ID:
M05-102L
Published:
04-27-2011
Last Updated:
05-16-2018

Patent Information

App Type:
Non-Provisional
Serial No.:
09/026,788
Patent No.:
6,014,449
File Date:
02-20-1998
Issue Date:
01-11-2000
Expire Date:
02-20-2018

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