Halistatins 1, 2 & 3
Description:
Contact
Jack Geltosky, PhD
Senior Vice President of Business Development, Life Sciences
Arizona Technology Enterprises, LLC (AzTE)
P: 480.884.1989
F: 480.884.1984
JGELTOSKY@AZTE.COM
Inventors
George Pettit, PhD
Regents Professor
Department of Chemistry and Biochemistry
Arizona State University
Rui Tan
Feng Gao
Yoshitatsu Ichtihara
Halistatins 1, 2 and 3
AzTE Cases # 626, 627, 701
Intellectual Property Status:
U.S. Patent 5,426,194
U.S. Patent 5,352,804
U.S. Patent 5,519,050
Invention Description
Halistatins are highly potent polyether macrolides with anti-mitotic actions that were originally isolated from certain marine sponges. Similar polyether macrolides, such as, Bryostatin 1 (Ph2), Halichondrin B (PC) and its analog, E7389 (Ph 2), are being tested both preclinically and clinically as anti-cancer agents.
Halistatin 1 has highly potent cytotoxic activity
in vitro against P388 cells (ED50 of 4x10-4 μg/mL) and against 60 human cancer cell lines from the NCI’s anti-tumor screening panel (average overall panel GI50 of 7x10-10 M).Halistatin 2 has highly potent cytotoxic activity
in vitro against P388 cells (ED50 of 4x10-4 μg/mL) and against 60 human cancer cell lines from the NCI’s anti-tumor screening panel (average overall panel GI50 of 7x10-10 M).Halistatin 3 strongly inhibits growth (ED
50 of 3.5x10-5 μg/mL) of P388 leukemia cells and a ‘mini’ panel of human cancer cell lines (GI50, μg/mL): brain (SF-295, 3.5x10-5), lung (NCI-460, 2.5x10-5), colon (KM 2062, 5.1x10-6), ovary (OVCAR-3, 1.3x10-5), renal (A498, 5.6x10-5) and melanoma (SK-MEL-5, 2.5x10-5).Potential Applications
These novel compounds have applications as:
Benefits and Advantages
- Case ID:
- Halistatins
- Published:
- 03-22-2010
- Last Updated:
- 05-07-2020
Inventor(s):
George (Bob) PettitCategories
Life Science (All LS Techs)For More Information, Contact
- Tom Goodman
- thomas.goodman@skysonginnovations.com
- 480 884 1648