Multi-Frequency Magnetic Resonance Electrical Impedance Tomography

Description:

­Low-frequency electrical properties of biological tissues provide sensitive and valuable cellular information as well as the presence or absence of disease. Measurements of variations in these properties provide a unique view of tissue state. Unfortunately, most efforts to image tissue electrical properties in the 10 Hz to 500 kHz frequency range are invasive and often error-prone. While some magnetic resonance-based methods of imaging electrical property distributions have been described, they can only be used at very high (>100 MHz) or very low (<100 Hz) frequencies.
 
Professor Rosalind Sadleir, at Arizona State University, has developed a novel MRI method that creates high-resolution imaging of electrical conductivity distributions at frequencies between low and high frequencies. This method enables non-invasive imaging of properties to aid in cancer diagnoses and help in planning cancer treatments. This technique has been validated using computational models, cell and tissue phantoms and in-vivo using a rat model of glioblastoma.
 
This innovative MRI method realizes high-resolution imaging of electrical conductivity distributions to enable non-invasive imaging to aid in both cancer diagnosis and treatment.
 
Potential Applications
  • Cancer detection, response characterization and monitoring
  • Planning and monitoring electrical therapies, particularly for treating brain cancers
    • Electroporation and transcranial electrical stimulation
  • Diagnosing ischemic stroke
  • Neuromodulation treatment planning
  • Research to better understand tumor properties
 
Benefits and Advantages
  • This approach can distinguish spectral effects
  • Imaging of electrical properties combined with electrical spectroscopy allows for subtle examination of both spatial and time-dependent tissue characteristics which may be important in the diagnosis and therapy regimen of cancers and other diseases
  • Non-invasively image electrical spectra over the frequency range from 10 Hz to 500 kHz at high resolution
  • The ability to understand tissue electrical conductivity dependence below 1 MHz results in improved sensitivity and specificity in planning and monitoring electrical therapies
 
For more information about the inventor(s) and their research, please see
 

 

Case ID:
M22-077LC^
Published:
09-20-2022
Last Updated:
09-20-2022

Inventor(s):

Rosalind Sadleir

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