Systems for Multiplexed Analysis of Biological Samples
Description:
- Molecular diagnostics & prognostics
- Targeted therapies (monitoring the effect of treatments)
- Basic biological studies (systems biology, cell heterogeneity, signaling pathway analysis, and more)
- Fluorescent tags for different biology probes in:
- Protein quantification
- DNA or RNA in situ hybridization & metabolic analyses
- 88 times more sensitive than direct immunofluorescence
- 35 times more sensitive than indirect immunofluorescence
- High signal removal efficiency - over 95% removed by mild chemical reagents while preserving the integrity of the epitopes on protein targets
- Measures cell-to-cell variations of proteins/nucleic acids as opposed to population-based measurements
- Can detect 50-100 different proteins/nucleic acids expressed at different levels in the same tissue/biological sample
- High sensitivity detection of low-abundant proteins or short RNAs
- Can be used with cultured cells and formalin fixed tissues
- Reduced imaging and overall assay time
- Potential side reactions with cellular nucleophiles can be prevented
- Enables accurate quantification of multiple proteins
- Case ID:
- M21-184LC^
- Published:
- 05-03-2022
- Last Updated:
- 05-12-2022
Categories
Applied Technologies Bioanalytical Assays, Chemistries & Devices Diagnostic Assays/Devices Life Science (All LS Techs) Chemical/Biological Sensors Imaging Proteomic Assays/Reagents/ToolsFor More Information, Contact
- Jovan Heusser
- jheusser@asu.edu